Harper's was founded in 1997 by rare-book dealer Harper Levine as Harper's Books in East Hampton, dedicated to exploring relationships between fine art and print media. The East Hampton location remains active, combining exhibitions with a rare-books program. Harper's expanded into New York City in 2016 with an Upper East Side space, began formally representing artists in 2017, and now operates two Chelsea galleries, opened in 2020 and 2022, alongside a dedicated books location. In 2026 the gallery opened its first international outpost in Bangkok. Harper's is led by Levine with directors Sarah Han, Chris Mansour, and Josh Rome.